Notify me of followup comments via e-mail. Thank you, {{form.email}}, for signing up. Selected from data included with permission and copyrighted by First Databank, Inc. Assuming you’ve been using other substances with Lamictal – are you sure that those other agents aren’t contributing to your weight change? Among persons who are prone to experiencing weight loss on Lamictal, research indicates that average weight loss ranges from: 2.58 lbs. Does Lamictal (Lamotrigine) Cause or Treat Anxiety? ... diarrhea, headache, general pain, runny nose, unusual weight loss, trouble sleeping or insomnia, menstrual pain, … Weight loss is a more common side effect than weight gain (which is comparatively rare). It is also used off-label as an adjunct in treating clinical depression. (0.6 kg) with placebo. Cannabidiol (CBD) Side Effects & Adverse Reactions, L-Tyrosine Side Effects & Adverse Reactions (List), Armour Thyroid Side Effects & Adverse Reactions (List), Remeron (Mirtazapine) Withdrawal Symptoms + How Long They Last, Source: https://www.ncbi.nlm.nih.gov/pubmed/23236017, Source: https://www.ncbi.nlm.nih.gov/pubmed/19357528, Source: https://www.ncbi.nlm.nih.gov/pubmed/17955096, Source: https://www.ncbi.nlm.nih.gov/pubmed/16566621, Source: https://www.ncbi.nlm.nih.gov/pubmed/16816224, Source: https://www.ncbi.nlm.nih.gov/pubmed/16542188, Source: https://www.ncbi.nlm.nih.gov/pubmed/16234878, Source: https://www.ncbi.nlm.nih.gov/pubmed/14756579. Nevertheless, evidence is based upon average responses to the medication – and does not account for individual variability in reactions. Research suggests that Lamictal modifies neurochemistry by: inhibiting voltage-gated sodium channels, blocking various calcium channels (L-type; N-type; P-type), antagonizing sigma and 5-HT3 receptors, upregulating GABA signaling, and suppressing the release of glutamate and aspartate. 2006: Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. (6.1 kg) with lithium treatment; and weight loss of 1.32 lbs. Data for the retrospective analysis was derived from multiple double-blind, placebo-controlled, 18-month trials testing lamotrigine and lithium for the management of bipolar disorder. Lamictal) users exhibited no significant changes in body weight. The most weight gain reported in a clinical trial participant receiving Lamictal was ~2.2 lbs. The phase IV clinical study is created by eHealthMe based on reports of 63,927 people who have side effects when taking Lamictal from the FDA, and is updated regularly. If you experience substantial weight change from Lamictal , share this reaction with a medical doctor. In the event that you experience weight change (gain or loss) while using Lamictal, included below is a list of possible reasons for that change. I Want to Stop Eating: Do I Have an Eating Disorder? Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Because lamotrigine doesn’t generally cause weight gain, Merideth organized a trial to determine the effectiveness of lamotrigine compared to placebo for the induction of weight loss among adults with obesity. I've been on lamictal for a few months now and have noticed extreme loss in appetite. ... black or tarry stool, blood in the stool or urine, rapid weight gain, feeling short of breath or having trouble breathing, irregular heart rhythm or chest pain, dark urine or decreased/stopped urination. If you're concerned that taking the medication Lamictal (lamotrigine) may cause you to gain weight, there's good news. – and obese users appear to lose more weight than non-obese users. The Superfood That Boosts Your Weight Loss Five Diet and Exercise Myths That Actually Make You Gain Weight Diabetes and weight loss Healthy Vegetarian Weight Loss For Total Noobs Why Smokers Get Fat When They Quit (And How To Avoid Post-Cigarette Weight … The findings in lamictal and vyvanse weight loss this group, increasing the risk for the analysis. Blurred vision 2. changes in vision 3. clumsiness or unsteadiness 4. double vision 5. poor coordination 6. skin rash 2006;67(2):258–262. 2013: Weight change associated with antiepileptic drugs. Merideth noted that, unlike most mood stabilizers, lamotrigine isn’t associated with weight gain. Sometimes a specific cause isn't found. Next post: Lamictal Side Effects & Adverse Reactions, Previous post: Lithium & Weight Gain: How Much? An Overview of Lamictal and Weight Gain Several side effects are possible with Lamictal ® (lamotrigine).Weight gain does appear to be one of them, although it is not among the most commonly reported Lamictal side effects.This data comes from clinical trials where the drug was extensively studied and side effects were documented. Always feeling tired? Int Clin Psychopharmacol. I used to eat a lot and now I can barely stomach half a sandwich. Read our, Medically reviewed by Daniel B. Understand that a majority of evidence suggests that Lamictal is unlikely to cause clinically significant weight change (defined as 7% body weight change from baseline). In the first clinical trials involving the drug, 5% of adults with epilepsy lost weight while taking Lamictal, while between 1% and 5% of patients with bipolar I disorder gained weight while on the drug. The researchers didn't disclose how much weight the patients gained or lost. 2006: A single-center, double-blind, placebo-controlled evaluation of lamotrigine in the treatment of obesity in adults. However, cases have occurred in the absence of these factors [see Boxed Warning]. – and obese users appear to lose more weight than non-obese users. Although studies provide averages for how much weight individuals lose or gain throughout trials – they do not account for individual variation. For example, several of them increase your blood sugar level, which can lead to weight gain. Pharmacology, adverse reactions, warnings and side effects. 2006;163(7):1199–1201. 2009;24(3):150–158. Get Lamictal Coupon Card by print, email or text and save up to 75% off Lamictal at the pharmacy. Find reviews for Lamotrigine from other patients. The patients received either: lamotrigine, lithium, or a placebo for the 18-month duration. The weight loss is a side affect because it can disrupt hormone balance. Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved. Among persons who are prone to experiencing weight loss on Lamictal, research indicates that average weight loss ranges from: 2.58 lbs. See below for a comprehensive list of adverse effects. (0.31 kg). for the placebo recipients. Therefore, if you're already overweight, you and your psychiatrist may want to consider the possibility of additional weight gain in determining your medication regimen for your bipolar disorder. Postgrad Med. 2009: Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial. … When used properly it can be very effective for calming the muscle spasms and convulsions that accompany most epileptic episodes. lamictal - weight loss or gain? Those taking Lamictal lost more weight than those on the placebo (about 2.5 pounds versus about one-third of a pound), and they did have significant improvements in their blood sugar and cholesterol lab test results. (0.5 kg) with lamotrigine; weight gain of 2.42 lbs. The good news for prospective Lamictal users is that, according to research, Lamictal is unlikely to cause significant weight change – and if weight change does occur, it’s most likely to be modest weight loss. Therefore, it is important that the dosing recommendations be followed closely. The drug seems ineffective in the treatment of current rapid-cycling, acute mania, or acute depression in bipolar disorder. Dealing with racing thoughts? Am J Psychiatry. lamotrigine). HIV testing and submission to NHSN during 2018 to May 21, 2020. doi:10.1176/appi.ajp.163.7.1199, Hasnain M, Vieweg WV. If you're concerned that taking the medication Lamictal (lamotrigine) may cause you to gain weight, there's good news. Weight change associated with antiepileptic drugs. The ideas, procedures, and suggestions contained within this work are not intended as a substitute for consulting with a medical doctor. Subscribe now in to enjoy this feature. Seroquel (Quetiapine) Drug Warnings and Side Effects, What to Know About Depakote Before You Start Taking It, Recovering from an Eating Disorder When You Live in a Larger Body, Daily Tips for a Healthy Mind to Your Inbox, Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial, Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer, Prescribing Information. Potential and/or hypothetical causes for weight change on Lamictal include: appetite change; gastrointestinal reactions; hormone fluctuations; changes in energy level; altered taste perception; and/or shifts in resting metabolic rate. Meanwhile, a 2006 study comparing the effects on weight of Lamictal, lithium, and a placebo found that obese patients taking Lamictal lost an average of four pounds, while non-obese patients' weight remained essentially the same., Weight gain from drugs used to treat bipolar disorder is unfortunately pretty common. In fact, some researchers even have looked at the drug as a possible treatment for obesity and as a treatment for binge-eating disorder.. For the study, researchers conducted a post-hoc analysis of data from a 12-week open-label study comprised of 1175 patients (with bipolar 1 disorder) using lamotrigine to treat symptoms. Our guide offers strategies to help you or your loved one live better with bipolar disorder. If anything, you're more likely to lose weight because of Lamictal than to gain weight, but either way, the changes will probably be pretty small. Included below are trials and/or reports in which the effect of Lamictal on body weight was evaluated or discussed. Researchers concluded that lamotrigine’s effect on body weight is analogous to that of a placebo. Through the aforementioned mechanisms of action, Lamictal effectively prevents seizures and stabilizes mood. Block, MD, Verywell Mind uses cookies to provide you with a great user experience and for our. (4.2 kg) with lamotrigine treatment; weight gain of 13.44 lbs. Learn from their experiences about effectiveness, side effects and cost. While Lamictal is regarded as a highly effective anticonvulsant for the management of neurological disorders, and is even classified as an “essential medicine” by the World Health Organization (WHO), some prospective users may be concerned about its side effects – including body weight change – including weight gain and weight loss. After a week and a half, I had to stop taking it. (1.2 kg) over a 52-week span. A total of 40 individuals were recruited to participate in the trial and randomly assigned to receive either: lamotrigine (200 mg per day) or a placebo – for a 26-week span. Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer. Pickrell, Lacey, Thomas, et al. I have recently started taking Lamictal for bipolar, 25mg the first week and am now at 50mg until I see my pdoc next month. Moreover, lamotrigine users were satisfied with the medication and reported no significant unwanted side effects. Moreover, if you’ve gained or lost weight from Lamictal – what do you think the reasons are for the weight change? doi:10.4088/jcp.v67n0212. , studied at Bournemouth University. Weight considerations in psychotropic drug prescribing and switching. Weight loss could be due to a combination of: nausea, vomiting, diarrhea, appetite reduction, etc. Based upon available medical research, Lamictal is likely to have no clinically significant effect on body weight. Results indicated that lamotrigine recipients exhibited no significant change in body weight; weight remained stable throughout the 18 months. You, as a reader of this website, are totally and completely responsible for your own health and healthcare. reviewed data from 8 placebo-controlled clinical trials (comprised of 1800 participants) and 4 unpublished studies in which lamotrigine was administered to treat bipolar disorder. But few studies have actually looked at how weight loss affects these patients’ long-term health, including their risk of heart disease (the most common … It was noted that lamotrigine was well-tolerated and unlikely to cause adverse reactions. After you began taking Lamictal, how long did it take for you to notice a change in body weight? Can People of Higher Weights Be Anorexic? Marcia Purse is a mental health writer and bipolar disorder advocate who brings strong research skills and personal experiences to her writing. Data from the study revealed no changes in body weight or BMI associated with lamotrigine treatment – regardless of whether administered as a standalone or adjunct (with valproate, antipsychotics, lithium or antidepressants). (And Why It Happens), Fetzima (Levomilnacipran) & Weight Loss vs. Gain, Does Mirena Cause Weight Gain? The open-label study included a 5-week titration phase with a target dose of lamotrigine set at 200 mg per day. On the other hand, if you lost weight while taking Lamictal, you may end up gaining weight in withdrawal. For this reason, it’s possible that you could be an outlier and end up experiencing significant weight change on Lamictal. 2006: Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorder. Guerdjikova, McElroy, Welge, et al. As you’ll read, none of the available data indicate that Lamictal causes weight gain. Unlike most mood stabilizers, though, Lamictal is less likely to cause weight gain. People with type 2 diabetes are often encouraged to lose weight, as this can help return their blood sugar to normal levels. Find everything you need to know about Lamictal (Lamotrigine), including what it is used for, warnings, reviews, side effects, and interactions. You can also subscribe without commenting. Does Taking Lithium for Bipolar Disorder Cause Weight Gain? It was further stated that 12.1% of lamotrigine recipients exhibited clinically significant weight loss as a result of treatment. The aforementioned researchers conducted a retrospective observational analysis with electronic primary healthcare records from over 1 million adult patients in Wales – all of whom were over the age of 18 and diagnosed with epilepsy. On that basis alone, Lamictal may be a good choice. U.S. Food & Drug Administration. I was prescribed Lamictal for anxiety and bipolar II. 2007: Effectiveness and weight effects of open-label lamotrigine with and without concomitant psychotropic medications in patients with bipolar I disorder. That said, it was further mentioned that lamotrigine appears to be weight neutral. If anything, you're more likely to lose weight because of Lamictal than to gain weight, but either way, the changes will probably be pretty small. (1 kg), and the highest average weight gain in a single trial was 0.68 lbs. Though this was a very small-scale study, it supports the idea that Lamictal could cause weight loss of ~2.58 lbs. Of the 1800 trial participants, 827 received lamotrigine as a monotherapy or adjunct for an 18-month duration. conducted a study to investigate the safety and effectiveness of Lamictal for the treatment of binge eating disorder (BED) associated with obesity. Bowden, Asnis, Ginsberg, et al. To help others fully understand the details associated with your Lamictal use, mention things like: how long you’ve used Lamictal; your Lamictal dosage; whether you use other substances with Lamictal; and whether you are currently underweight, overweight, or obese. If you ended up experiencing weight loss or weight gain while using Lamictal, document the specific amount of weight change that you experienced in the comments section below. J Clin Psychiatry. Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. In the paper, the authors state that weight gain is a problematic side effect of many pharmaceutical medications in that increased body weight often compromises health of the user – and frequently interferes with treatment compliance. That said, if you are concerned about body weight change while using Lamictal – or have already experienced weight change, below are some weight management strategies to consider implementing. Journal of Neurology, Neurosurgery, and Psychiatry. This medication gives me a sense of balance and curbs the extreme shifts, as in rapid cycling. Specifically, researchers sought to determine how lamotrigine impacts weight when administered as a standalone, as well as when administered concurrently with another medication. It probably won't affect your weight much at all. over a 4-month span. Average weight changes as a result of lamotrigine administration ranged from -0.38 kg to +1 kg – for an overall average of +0.68 lbs. (And Why It Happens). Things you must do . Weight loss is found among people who take Lamictal, especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years. Communities > Bipolar Disorder > Lamictal weight loss. Symptoms of Lamictal overdose can include rapid, uncontrollable eye movements, clumsiness and lack of coordination affecting your balance, impaired or loss of consciousness, fits or coma. Did your weight change occur within a short-term followed by stabilization – or did the weight change occur gradually over a longer-term? sought to determine the effect of frequently-prescribed antiepileptic medications on the body weights of users. 2013 Jul;84(7):796-9. Most bipolar drugs cause weight gain rather than weight loss. Lamictal (lamotrigine) Tablets. Paul Reynolds. retrospectively analyzed the impact of lamotrigine treatment on body weight of persons with bipolar disorder. The body weights, BMIs, body fat percentages, serum lipids, and glycosylated hemoglobin levels of participants were recorded at baseline – and compared to measures following week 26. Lamictal also has been studied as a possible treatment for obesity in people without epilepsy or bipolar disorder. doi:10.1097/YIC.0b013e328329c7b5, Prabhavalkar KS, Poovanpallil NB, Bhatt LK. Those taking the placebo, meanwhile, lost around seven pounds, so while those taking Lamictal lost more weight, they didn't lose all that much more.. Unexplained weight loss has many causes, medical and nonmedical. Rapid weight loss for type 2 diabetes may harm some. This is very rare, and can even cause weight gain as well. In the trials, a total of 227 patients received lamotrigine, 166 received lithium, and 190 received a placebo. What’s more, lamotrigine recipients exhibited substantial reductions in fasting glucose, insulin, and triglycerides. In clinical trials, less than 5 percent of those taking Lamictal gained weight. to 9.25 lbs. (e.g. Sign up for our newsletter and get it free. There are suggestions, yet to be proven, that the risk of severe, potentially life-threatening rash may be increased by (1) coadministration of LAMICTAL with valproate, (2) exceeding the recommended initial dose of LAMICTAL, or (3) exceeding the recommended dose escalation for LAMICTAL. doi:10.3810/pgm.2013.09.2706, Merideth CH. Updated 2005. A. Milk samples from patients suspected of having severely low blood sugar, lamictal and vyvanse weight loss injecting insulin, and adjusting levels if the respondent completed the survey primarily is intended to be infected even if the. All matters regarding your health require medical supervision. appetite change; faster metabolism; increased energy; etc.). Others affect your energy level. caused weight gain (it did get me off the alprazolam though! Average change in body weight from baseline was -6.4 lbs. Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. A. Researchers then calculated patients’ body weight changes from baseline as a result of antiepileptic use. ... itchiness, runny nose, cough, nausea, indigestion, abdominal pain, weight loss, missed or painful menstrual periods, and vaginitis. The National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. Researchers assessed the data to determine whether lamotrigine was safe, effective, and tolerable among individuals with bipolar diagnoses. The BMIs of lamotrigine recipients decreased by 1.5, whereas the BMIs of placebo recipients decreased by just -0.1. (0.7 kg) with placebo. While you are taking it . Often, a combination of things results in a general decline in your health and a related weight loss. 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